Хибридни дуо

As members of the LP Duo, for the past 14 years we have experimented with various possibilities of playing on two pianos. Our artistic curiosity and the desire to gain new knowledge and freedom led to our involvement with the Quantum Music project and the creation of a new instrument – the hybrid piano. In this paper we elaborate on our experience with using the new hybrid pianos within the Quantum Music project, but also discuss our ensemble as an artistic embodiment of duality, entanglement and other quantum phenomena. Hybrid piano is a combination of a traditional piano and digital synthesizer with analogue controls that allows diferent processing of acoustic and digital signals in real time and enables the pianists to continue to use concert pianos whilst equipping them with new colours and new, hitherto unexlplored expressive possibilities.Београдски клавирски дуо Соња Лончар и Андрија Павловић (ЛП Дуо) већ четрнаест година експериментише са различитим могућностима свирања на два клавира. Поред класичног репертоара који је овај дуо прошао за време и након oсновних и специјалистичких студија на ФМУ у Београду а потом и на Високој школи за музику и позориште у Роштоку (Немачка), његови чланови су од самог почетка испољавали интересовање за савремену уметност, извођење дела композитора-савременика, бављење визуелним и примењеним уметностима (видео, филм, фотографија, музички перформанс, кореографије, позоришне представе), те свирање у ансамблима и музичким саставима различитих жанрова (рок, популарна, експериментална музика), као и свирање на различитим синтисајзерима. Њихов истраживачки дух и потреба за освајањем нових знања и слобода, као и сва наведена искуства, постепено су водила ка осмишљавању и реализацији пројекта Квантна музика и стварању новог инструмента – хибридног клавира. У овом раду чланови ЛП Дуа преносе своја искуства рада на пројекту Квантна музика и на развоју хибридног клавира, док у исто време свој ансамбл посматрају као отелотворење квантних феномена попут дуалности. Хибридни клавир је комбинација традиционалног клавира и дигиталног синтисајзера са аналогним контролама које омогућавају различито процесовање акустичких и дигиталних сигнала у реалном времену и омогућавају пијанистима да наставе да користе концертне клавире, али обогаћене новим бојама и досад незамисливим изражајним могућностима.Some parts of this article were incorporated into authors' (unpublished) doctoral dissertations: Lončar, Sonja (2018) „Hibridni duo – Novi prostori savremenog izvođaštva u ansamblu klavirski duo.“ [Hybrid Duo – New realms of contemporary performance for the piano duo.] Unpublished dissertation. Belgrade: Faculty of Music, University of Arts; Pavlović, Andrija (2018) „Savremeni izazovi rada i saradnje muzičara u klavirskom duu na primeru muzičko-scenskog projekta Kvantna muzika.“ [Contemporary challenges of work and collaboration between musicians in a piano duo, using the example of the music-scenic project Quantum Music.] Unpublished dissertation. Belgrade: Faculty of Music, University of Arts

OPTIMAL SYNTHESIS OF A MANIPULATOR USING TWO COMPETITIVE METHODS

This paper defines a program realization for finding the optimal geometry of a planar Z-mechanism. The paper shows the mathematical procedure for defining the objective function, the constraint function and the search fields which are used for solving the optimization problem. Starting from the solutions in practice, a numerical example is given to determine an optimum design with four optimization parameters. All the optimization parameters are geometric on the mechanism for defining the bucket position. The problem is solved by two different numerical methods - the method of formal search of hyperspace (passive scanning method) and the approximate method of Sequential Quadratic Programming - SQP (applying the function fminmax of the Matlab optimization toolbox). The verification is performed with animation using software for geometric modeling. The results are graphically illustrated

Analytical model of conductive graphite foam based sensors characteristics

Sensors play an important role in the control systems, because they provide the necessary information from surroundings to the controller of an automated systems. Today’s sensors are very sophisticated, with high accuracy, fast acquisition rate and good signal-to-noise ratio. But most of these sensors are too much expensive. Low cost sensor for measuring the force (pressure) or the displacement could be realized by utilizing conductive elastomer that exhibits property of changing the electrical resistance when the elastomer is deformed. This paper introduced a novel conductive graphite foam based sensors. The sensors are formed by inserting two thin copper wires within conductive foam, parallel to each other at the two opposite sides. The main problem of conductive foam based sensors is that the force-electrical resistance characteristic, or the displacement-electrical resistance characteristic, of conductive foam is highly nonlinear. This paper presents the analytical model of the conductive graphite foam sensors for measurement of the displacement. By measuring the changes in the electric resistance between two points of the foam and using the developed analytical model it should be possible to accurately estimate the displacement when the conductive foam is deformed

Brza progresija hronične limfocitne leukemije u Rihterov sindrom kod bolesnika sa kariotipom blizu triploidnog broja hromozom

Introduction. The presence of aneuploidy in patients diagnosed with chronic lymphocytic leukemia (CLL), except trisomy 12, is considered quite uncommon. Hyperdiploidy or near-tetraploidy (occurring in 1–3% of all CLL patients) usually confer a poor prognosis. Case report. We report a patient in a progressive phase of CLL with near–triploid karyotype. The prognosis of the disease was more precisely determined by applying the cytogenetic analysis of the karyotype and was complemented with molecular methods and pathohistological examination. The complex karyotype was accompanied by the TP53, C-MYC, and IGH gene disruptions, the most probable cause of rapid evolution into Richter’s syndrome. Conclusion. The use of comprehensive contemporary diagnostic techniques is highly recommended in patients who are in the progressive phase of CLL, primarily for the adequate choice of management strategy. The presented case confirms that aneuploidy in CLL patients indicates poor prognosis, which is in accordance with previous publications reporting on cases of CLL patients with aneuploidy.Uvod. Prisustvo aneuploidije kod bolesnika sa dijagnozom hronične limfocitne leukemije (HLL), sa izuzetkom trizomije 12, smatra se retkom pojavom. Pojava hiperdiploidnog ili kariotipa blizu tetraploidnog broja hromozoma (koji se javlja kod 1–3% svih bolesnika sa HLL) smatra se lošim prognostičkim parametrom. Prikaz bolesnika. Prikazan je bolesnik u uznapredovaloj fazi HLL sa kariotipom blizu triploidnog broja hromozoma. Prognoza bolesti je preciznije određena citogenetičkom analizom kariotipa bolesnika, i dopunjena molekularnim metodama i patohistološkom analizom. Otkriveno je prisustvo kompleksnog kariotipa udruženog sa poremećajima u genima TP53, C-MYC i IGH, što je najverovatnije bio uzrok brze progresije u Rihterov sindrom. Zaključak. Primena savremenih dijagnostičkih metoda veoma je značajna kod bolesnika u uznapredovaloj fazi HLL, prvenstveno zbog adekvatnog terapijskog pristupa. Prikazani slučaj ukazuje da je prisustvo aneuploidije kod bolesnika sa HLL loš prognostički znak, što je u saglasnosti sa prethodno publikovanim prikazima bolesnika sa HLL i sa aneuploidijom u kariotipu

CONTAMINATION OF SOILS OF ĐURĐEVAC SANDS BY HEAVY METALS

Na tlima Geografsko-botaničkog rezervata Đurđevački pijesci u tijeku 2006. i 2007. godine provedena su pedološka istraživanja u sklopu kojih je utvrđen ukupni sadržaj teških kovina (Zn, Cu, Cd, Pb, Ni i Cr). Također su izrađeni korelacijski i regresijski odnosi između ukupnog sadržaja istraživanih teških kovina i sadržaja humusa, kao i reakcije tla. Rezervat zauzima površinu od 19,5 ha. Krajem 19. i početkom 20. stoljeća eolski „živi“ pijesci Podravine od Đurđevca do Virovitice su pošumljeni, a time je narušena biološka i krajobrazna raznolikost ovog područja. U cilju obnove Geografsko-botaničkog rezervata na cca 6 ha odstranjena je nepoželjna vegetacija ili je strojno uklonjen humusno-akumulativni horizont, čime su pijesci djelomično obnovljeni. U široj okolici Rezervata nalaze se plinske i naftne bušotine, čije isplačne jame i njihove isplake sadrže različite toksične tvari rizične za okoliš. Istraživano je onečišćenje tala Rezervata navedenim teškim kovinama i uspoređeno je onečišćenje devastirane i uređene površine. Na temelju stupnja onečišćenja u pojedinačnim uzorcima tla, na čitavom području Rezervata utvrđeno je povećano onečišćenje bakrom, kadmijem i niklom, te veliko kromom. U Rezervatu je iz pojedinačnih uzoraka u površinskom horizontu utvrđeno najveće onečišćenje kromom, a najmanje olovom. Do 30 cm dubine tla na uređenoj površini ustanovljen je prosječno veći ukupni sadržaj bakra i olova te prosječno manji ukupni sadržaj cinka, kadmija, nikla i kroma. Najjači pozitivni korelacijski odnos utvrđen je između reakcije tla mjerene u vodi i ukupnog sadržaja bakra, a negativan je u odnosu na ukupni sadržaj nikla. Također je utvrđen najjači pozitivni korelacijski odnos između sadržaja humusa i ukupnog sadržaja kadmija, a negativni između sadržaja humusa i ukupnog sadržaja nikla. U radu se predlažu smjernice za daljnje upravljanje Rezervatom.Pedological researches were conducted in geobotanical reserve Đurđevac sands during 2006. and 2007. in order to determine the total heavy metals content the (Zn, Cu, Cd, Pb, Ni and Cr). Correlation and regression relations were also worked out between total researched heavy metals, humus content, as well as soil reaction. The geobotanical reserve occupies the area of 19.5 ha. At the end of 19th and the beginning of 20th century eolic shifting sands of the Podravina region from Đurđevac to Virovitica were forested, resulting in disruption of biological and landscape diversity of the area. In order to restore the nature reserve, unwanted vegetation was eliminated in 6 ha, or humus accumulative layer of the soil was removed, resulting in partial restoration of Đurđevac shifting sands. In the broader area of the geobotanical reserve there are several gas and oil wells,whose drilling mud excavations contain different toxic substances hazardous for environment. Contamination of the nature reserve with above mentioned heavy metals was researched and comparison of contamination was made for the devastated and restored area. According to the level of contamination with by these heavy metals in individual soil samples from the whole area, encreased contamination with Copper, Cadmium and Nickel, and a high contamination with Chromium, was determined. The highest contamination of soils of the nature reserve, determined from individual soil samples of surface layer, was with Chromium, and the least with Lead. In the restored area bigger Copper and Lead total content of was determined on the average below of 30 cm soil depth and smaller total of Zinc, Cadmium, Nickel and Chromium content. The strongest positive correlation relation was determined among reaction of soil measured in water and total content of Copper, and negative one in relation to total Nickel content. The strongest positive correlation was also determined between the amount of humus and total Cadmium content, and negative one the amount of humus and total Nickel content. The paper proposes directives for the future management of the nature reserve

CONTAMINATION OF SOILS OF ĐURĐEVAC SANDS BY HEAVY METALS

Na tlima Geografsko-botaničkog rezervata Đurđevački pijesci u tijeku 2006. i 2007. godine provedena su pedološka istraživanja u sklopu kojih je utvrđen ukupni sadržaj teških kovina (Zn, Cu, Cd, Pb, Ni i Cr). Također su izrađeni korelacijski i regresijski odnosi između ukupnog sadržaja istraživanih teških kovina i sadržaja humusa, kao i reakcije tla. Rezervat zauzima površinu od 19,5 ha. Krajem 19. i početkom 20. stoljeća eolski „živi“ pijesci Podravine od Đurđevca do Virovitice su pošumljeni, a time je narušena biološka i krajobrazna raznolikost ovog područja. U cilju obnove Geografsko-botaničkog rezervata na cca 6 ha odstranjena je nepoželjna vegetacija ili je strojno uklonjen humusno-akumulativni horizont, čime su pijesci djelomično obnovljeni. U široj okolici Rezervata nalaze se plinske i naftne bušotine, čije isplačne jame i njihove isplake sadrže različite toksične tvari rizične za okoliš. Istraživano je onečišćenje tala Rezervata navedenim teškim kovinama i uspoređeno je onečišćenje devastirane i uređene površine. Na temelju stupnja onečišćenja u pojedinačnim uzorcima tla, na čitavom području Rezervata utvrđeno je povećano onečišćenje bakrom, kadmijem i niklom, te veliko kromom. U Rezervatu je iz pojedinačnih uzoraka u površinskom horizontu utvrđeno najveće onečišćenje kromom, a najmanje olovom. Do 30 cm dubine tla na uređenoj površini ustanovljen je prosječno veći ukupni sadržaj bakra i olova te prosječno manji ukupni sadržaj cinka, kadmija, nikla i kroma. Najjači pozitivni korelacijski odnos utvrđen je između reakcije tla mjerene u vodi i ukupnog sadržaja bakra, a negativan je u odnosu na ukupni sadržaj nikla. Također je utvrđen najjači pozitivni korelacijski odnos između sadržaja humusa i ukupnog sadržaja kadmija, a negativni između sadržaja humusa i ukupnog sadržaja nikla. U radu se predlažu smjernice za daljnje upravljanje Rezervatom.Pedological researches were conducted in geobotanical reserve Đurđevac sands during 2006. and 2007. in order to determine the total heavy metals content the (Zn, Cu, Cd, Pb, Ni and Cr). Correlation and regression relations were also worked out between total researched heavy metals, humus content, as well as soil reaction. The geobotanical reserve occupies the area of 19.5 ha. At the end of 19th and the beginning of 20th century eolic shifting sands of the Podravina region from Đurđevac to Virovitica were forested, resulting in disruption of biological and landscape diversity of the area. In order to restore the nature reserve, unwanted vegetation was eliminated in 6 ha, or humus accumulative layer of the soil was removed, resulting in partial restoration of Đurđevac shifting sands. In the broader area of the geobotanical reserve there are several gas and oil wells,whose drilling mud excavations contain different toxic substances hazardous for environment. Contamination of the nature reserve with above mentioned heavy metals was researched and comparison of contamination was made for the devastated and restored area. According to the level of contamination with by these heavy metals in individual soil samples from the whole area, encreased contamination with Copper, Cadmium and Nickel, and a high contamination with Chromium, was determined. The highest contamination of soils of the nature reserve, determined from individual soil samples of surface layer, was with Chromium, and the least with Lead. In the restored area bigger Copper and Lead total content of was determined on the average below of 30 cm soil depth and smaller total of Zinc, Cadmium, Nickel and Chromium content. The strongest positive correlation relation was determined among reaction of soil measured in water and total content of Copper, and negative one in relation to total Nickel content. The strongest positive correlation was also determined between the amount of humus and total Cadmium content, and negative one the amount of humus and total Nickel content. The paper proposes directives for the future management of the nature reserve

Acute promyelocytic leukemia lacking t(15;17): Molecular evidence of atypical PML/RAR-α transcriptional variant by gene sequencing

Uvod. Precizno dijagnostikovanje akutne promijelocitne leukemije (APL), ne samo na osnovu morfoloških i kliničkih parametara, već i na molekularnom nivou, veoma je važno radi primene adekvatne ciljane terapije. Prikaz bolesnika. Prikazali smo bolesnicu, staru 62 godine, sa dijagnozom APL. Primenom standardne citogenetičke analize, kao i primenom fluorescentne in situ hibridizacije (FISH), nije bilo potvrđeno prisustvo t(15;17) kod opisane bolesnice. Primenom metode reverzna transkriptazalančana reakcija polimeraze (RT-PCR), identifikovana su dva atipična promyelotic leukemia/retinoic acid receptor alpha (PML/RAR-α) fuziona transkripta. Oba transkripta su predstavljala izoforme. Duži transkript je zadržao "okvir čitanja" i kodirao je funkcionalan PML/RAR-α aberantni protein, dok je kraći transkript bio van "okvira čitanja". Zaključak. Naša studija ukazuje na potrebu za primenom molekularne metodologije u svakodnevnoj kliničkoj praksi. Precizna karakterizacija PML/RAR-α fuzionih transkipta čini osnovu za identifikovanje retkih bolesnika čije lečenje zahteva dodatni oprez. Prema našim saznanjima, ovo je tek peti slučaj opisanog atipičnog PML/RAR-α transkripta koji u sebi sadrži celokupan PML egzon 7a, a među njima jedini koji se nije mogao detektovati primenom citogenetičke i FISH analize. Svi ovde predstavljeni slučajevi su imali smrtni ishod. Zbog toga, naši rezulatati, zajedno sa sličnim slučajevima opisanim u literaturi, naglašavaju značaj detaljne identifikacije atipičnih PML/RAR-α fuzija, ne samo u svrhu prepoznavanja njihove uloge u procesu leukemogeneze, veći i u smislu procene njihovog uticaja na ishod lečenja.Introduction. The accurate diagnosis of acute promyelocytic leukemia (APL), not only on the morphological and clinical, but also on the molecular level, is very important for application of targeted therapies. Case report. A 62year-old woman presented with APL. By using conventional cytogenetic analysis as well as applying the fluorescence in situ hybridization (FISH) analysis it has not been possible to confirm the presence of t(15;17) in the presented patient. Using reverse transcriptase polymerase chain reaction (RT-PCR) two atypical promyelotic leukemia/retinoic acid receptor alpha (PML/RAR-α) fusion transcripts were identified. Both detected transcripts were isoforms. The larger transcript was in-frame, coding for functional aberrant PML/RAR-α protein, while the shorter transcript was an out-of-frame. Conclusion. Our study highlights the need for the application of molecular methodology in daily clinical practice. Precise characterization of PML/RAR-α fusion transcript creates a basis for identifying rare individual cases that require special caution when treating such patients. To our knowledge this is only the fifth case of atypical PML/RAR-α transcript containing full PML exon 7a, and among them the only one that was cytogenetically cryptic and FISH negative. All of the herein presented cases had lethal outcome. Therefore, our findings with the additional review of the literature, emphasizes the importance of detailed identification of atypical PML/RAR-α fusions, not only for the purpose of knowing their role in leukemogenesis, but also for the assessment of the impact that they can have on the outcome of the treatment

Allelopathic potential of selected woody species growing on fly-ash deposits

The objective of this study was to determine the allelopathic potential of Robinia pseudoacacia L., Ailanthus altissima (Mill.) Swingle and Amorpha fruticosa L. that grow on the fly-ash deposits at the “Nikola Tesla – A” thermoelectric power plant in Obrenovac. The chemical characteristics of fly ash, such as pH, electrical conductivity (EC), content of carbon (C) and nitrogen (N), contents of available phosphorus (P2O5) and potassium (K2O), the contents of total and available Fe, Cu, Mn, Ni and Zn as well as of phenolic acids (3,5 dihydroxybenzoic acid (3,5-DHBA) and ferulic acid) and flavonoids (rutin and quercetin) were analyzed in control fly ash (bare zones without vegetation cover) and plant rhizospheric fly ash. In order to determine the allelopathic activity of phenolic compounds in fly ash, modified soil sandwich allelopathic biotests were performed, and Trifolium pratense L. (red clover) was used as the indicator species. A. fruticosa showed the highest allelopathic activity, followed by A. altissima whereas R. pseudoacacia showed the lowest allelopathic potential. Negative correlation was noted between radicle and hypocotyl growth inhibition of red clover and the pH of fly ash. Positive correlations were found between radicle growth inhibition and the content of C, P2O5, total concentrations of Cu, available concentrations of Mn and Ni, the contents of ferulic acid, 3,5-DHBA, and rutin. Our results indicate that A. fruticosa and A. altissima increased the content of phenolics in fly ash, which can act as allelochemicals leading to radicle growth inhibition of red clover in the pioneer plant community on fly-ash deposits. These woody species that colonized fly-ash deposits can initiate the beginning of pedogenetic processes altering the ecosystem processes at degraded site